|
rs3025058
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With MMP-3 promoter polymorphism (rs3025058), a lower peripheral blood platelet count, which was related to advanced liver cirrhosis, was observed in 5A carriers.
|
17763953 |
2008 |
|
rs4898
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used PCR to analyze 188 patients with HCV-related liver disease (95 with chronic hepatitis and 93 with cirrhosis) for TIMP-1 372 T/C and TIMP-2 -418 G/C polymorphisms.
|
23563628 |
2013 |
|
rs72613567
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We tested the association of rs72613567 with plasma levels of alanine transaminase (ALT) and clinical liver disease and mortality in 111,612 individuals from the Danish general population, including 497 with cirrhosis and 113 with hepatocellular carcinoma.
|
31155741 |
2020 |
|
rs1140409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We recently identified a missense single nucleotide polymorphism (SNP) in DDX5 (rs1140409, p.S480A) that enhances the risk of developing cirrhosis.
|
20022962 |
2010 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We identified variants in the MBOAT7 (P = 1.03 × 10(-9)) and TM6SF2 (P = 7.89 × 10(-10)) genes as new risk loci and confirmed rs738409 in PNPLA3 as an important risk locus for alcohol-related cirrhosis (P = 1.54 × 10(-48)) at a genome-wide level of significance.
|
26482880 |
2015 |
|
rs10146249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found three differentially distributed SNPs (rs8021276, rs7158733, and rs10146249) via the screening analysis; however, only rs8021276 polymorphism was further identified to modify the risk of LC.
|
29937988 |
2018 |
|
rs7158733
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found three differentially distributed SNPs (rs8021276, rs7158733, and rs10146249) via the screening analysis; however, only rs8021276 polymorphism was further identified to modify the risk of LC.
|
29937988 |
2018 |
|
rs10433937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that SERPINA1 Pi*S variant conferred an increased risk of developing liver fibrosis, while SERPINA1 Pi*Z and HSD17B13 rs10433937 were not associated with liver fibrosis or cirrhosis of different aetiology.
|
31517326 |
2019 |
|
rs7664413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a significantly (P = 0.021) higher risk for HCC was shown in individuals with the VEGF-C rs1485766 A/A genotype compared to those with wild-type homozygotes; a high frequency of an advanced stage and a low frequency of being positive for cirrhosis were respectively shown in HCC patients with the VEGF-C rs7664413 CT/TT and rs3775194 GC/CC genotypes.
|
24478168 |
2014 |
|
rs1485766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a significantly (P = 0.021) higher risk for HCC was shown in individuals with the VEGF-C rs1485766 A/A genotype compared to those with wild-type homozygotes; a high frequency of an advanced stage and a low frequency of being positive for cirrhosis were respectively shown in HCC patients with the VEGF-C rs7664413 CT/TT and rs3775194 GC/CC genotypes.
|
24478168 |
2014 |
|
rs1358379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1358379 was associated with susceptibility to HBV infection, HBV clearance, persistent chronic HBV infection and liver cirrhosis+HCC.
|
28685993 |
2017 |
|
rs7536540
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We find that the rs7536540 polymorphism in miR-101-1 is significantly associated with development of liver cirrhosis and hepatocellular carcinoma occurrence.
|
22658643 |
2012 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the relationship between genetic polymorphisms of the renin-angiotensin system (A1166C angiotensin II type 1 receptor (AT1R), angiotensinogen T174M and M235T, and angiotensin-converting enzyme I/D) and the effects of losartan on portal and systemic hemodynamic in patients with cirrhosis and portal hypertension.
|
15743363 |
2005 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the relationship between genetic polymorphisms of the renin-angiotensin system (A1166C angiotensin II type 1 receptor (AT1R), angiotensinogen T174M and M235T, and angiotensin-converting enzyme I/D) and the effects of losartan on portal and systemic hemodynamic in patients with cirrhosis and portal hypertension.
|
15743363 |
2005 |
|
rs4762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the relationship between genetic polymorphisms of the renin-angiotensin system (A1166C angiotensin II type 1 receptor (AT1R), angiotensinogen T174M and M235T, and angiotensin-converting enzyme I/D) and the effects of losartan on portal and systemic hemodynamic in patients with cirrhosis and portal hypertension.
|
15743363 |
2005 |
|
rs236918
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We evaluated the associations between the PNPLA3 (rs738409), RNF7 (rs16851720), MERTK (rs4374383) and PCSK7 (rs236918) variants and liver fibrosis and cirrhosis in a series of consecutive patients recruited at the Department of Gastroenterology, Lithuanian University of Health Sciences Hospital, during the period 2012-2015.
|
28338112 |
2017 |
|
rs4374383
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We evaluated the associations between the PNPLA3 (rs738409), RNF7 (rs16851720), MERTK (rs4374383) and PCSK7 (rs236918) variants and liver fibrosis and cirrhosis in a series of consecutive patients recruited at the Department of Gastroenterology, Lithuanian University of Health Sciences Hospital, during the period 2012-2015.
|
28338112 |
2017 |
|
rs1800872
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conducted a case-control study to investigate the association between three common SNPs in IL-10 gene (rs1800896, rs1800871 and rs1800872) and the development of liver cirrhosis in a Chinese population.
|
26617910 |
2015 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a case-control study to investigate the association between three common SNPs in IL-10 gene (rs1800896, rs1800871 and rs1800872) and the development of liver cirrhosis in a Chinese population.
|
26617910 |
2015 |
|
rs1800872
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conducted a case-control study to assess the role of two IL10 gene polymorphisms (rs1800896 and rs1800872) in susceptibility to liver cirrhosis, and their association with chronic hepatitis B in a Chinese population.
|
26909998 |
2016 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a case-control study including 433 subjects (171 healthy controls, 130 patients with chronic hepatitis B [CHB]; and 132 patients with HBV-related liver cirrhosis [HBV-LC] to assess the association between IL-17A rs4711998, IL-17A rs2275913 and IL-17F rs763780 polymorphisms and risk of CHB and HBV-LC.
|
26546176 |
2016 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a case-control study including 433 subjects (171 healthy controls, 130 patients with chronic hepatitis B [CHB]; and 132 patients with HBV-related liver cirrhosis [HBV-LC] to assess the association between IL-17A rs4711998, IL-17A rs2275913 and IL-17F rs763780 polymorphisms and risk of CHB and HBV-LC.
|
26546176 |
2016 |
|
rs4711998
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a case-control study including 433 subjects (171 healthy controls, 130 patients with chronic hepatitis B [CHB]; and 132 patients with HBV-related liver cirrhosis [HBV-LC] to assess the association between IL-17A rs4711998, IL-17A rs2275913 and IL-17F rs763780 polymorphisms and risk of CHB and HBV-LC.
|
26546176 |
2016 |
|
rs376373278
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We assessed the role of the G(-463)A-MPO, T(-262)C-CAT, Ala16Val-SOD2, and Pro198Leu-GPx1 variants in modulating HCC development in patients with HCV-induced cirrhosis.
|
21907168 |
2012 |
|
rs972427414
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We assessed the role of the G(-463)A-MPO, T(-262)C-CAT, Ala16Val-SOD2, and Pro198Leu-GPx1 variants in modulating HCC development in patients with HCV-induced cirrhosis.
|
21907168 |
2012 |